Why You’ll Love Cowboy Biscuit Casserole Recipe

This casserole combines familiar flavors in a fun, layered bake that feels a bit like a cross between shepherd’s pie and a cheesy biscuit dish. It’s easy to prepare, feeds a crowd, and delivers creamy, savory goodness in every bite. The rich sauce with sour cream and cheese makes it extra comforting, and the buttery biscuits on the bottom bring a crowd‑pleasing twist.

Ingredients

(Tip: You’ll find the full list of ingredients and measurements in the recipe card below.)

Red Lobster Cheddar Bay Biscuit Mix
Olive oil
Onion, chopped
Garlic, chopped
Ground beef
Taco seasoning
Sour cream
Mayonnaise
Hand shredded cheddar cheese
Salt
Pepper
Garlic powder
Dried parsley

Directions

Preheat your oven to 350°F (175°C).
In a large bowl, combine the biscuit mix with water (following package instructions) and mix until combined. If you’re using a mix that comes with a seasoning packet, add the packet into the dough for extra flavor.
Press the biscuit dough into the bottom of a greased 9×13‑inch baking dish, flattening it evenly with your fingers.
Heat olive oil in a skillet over medium heat. Sauté the chopped onion and garlic until softened.
Add the ground beef to the skillet and cook it with the taco seasoning until browned and fully cooked.
Spread the seasoned beef mixture over the biscuit layer in the baking dish.
In a medium bowl, mix together sour cream, mayonnaise, shredded cheddar cheese, salt, pepper, and garlic powder until well combined. Pour this mixture over the beef layer and spread evenly.
Sprinkle additional shredded cheese on top.
Bake in the preheated oven for about 30–35 minutes, until the top is melted and bubbly and the edges are golden.
Let the casserole rest for about 5–10 minutes, then sprinkle with dried parsley and serve warm.

Servings and timing

This casserole typically serves about 6–8 people. It takes roughly 15 minutes to prepare and about 30–35 minutes to bake, for a total time of around 45–50 minutes.

Variations

Meat: Swap ground beef for ground turkey or chicken for a lighter option.
Cheese: Use your favorite shredded cheese blend — Monterey Jack, pepper jack, or a Mexican cheese mix all work well.
Veggies: Add a can of corn or a bag of frozen peas for more color and texture.
Spice: Stir in some chopped jalapeños or a dash of hot sauce to give it a kick.

Storage/Reheating

Storage: Cover leftover casserole tightly and store it in the refrigerator for up to 3–4 days.
Freezing: You can freeze the baked casserole for up to 2 months. Wrap it in foil or place it in an airtight container before freezing.
Reheating: Reheat individual portions in the microwave or warm the entire dish in a 350°F oven until heated through.

FAQs

What can I substitute for the biscuit mix?

You can use homemade biscuit dough or canned refrigerated biscuits if you don’t have a boxed mix.

Can I make this casserole ahead of time?

Yes — assemble it and refrigerate for a few hours before baking.

Is it okay to use pre‑shredded cheese?

Yes, but freshly shredded cheese melts more smoothly and gives a creamier texture.

Can I make this vegetarian?

Yes — swap the meat for a plant‑based ground beef, or use sautéed mushrooms and beans.

What other seasonings go well in this dish?

Try chili powder, cumin, or smoked paprika for extra flavor.

How do I know when it’s done?

The cheese should be melted and bubbly and the edges slightly golden.

Can I use gluten‑free biscuit mix?

Yes — just choose a gluten‑free biscuit mix and follow the same steps.

How do I prevent the bottom from getting soggy?

Make sure you press the biscuit dough firmly and cook the beef mixture until most liquids evaporate.

Can I add vegetables to this casserole?

Absolutely — bell peppers, corn, or peas are great additions.

What’s the best cheese for this recipe?

Sharp cheddar gives great flavor, but Colby Jack or a Mexican blend also works well.

Conclusion

Cowboy Biscuit Casserole brings together comforting flavors and simple preparation for a satisfying meal any night of the week. With layers of seasoned beef, creamy tangy sauce, and a tender biscuit base, it’s sure to become a favorite in your dinner rotation.